WHAT role elevated IL-6 can play in RA
Dysregulation of IL-6 signaling, as seen in patients with RA, has been associated with chronic inflammation and widespread effects. Persistently elevated IL-6 levels affect various physiologic processes and can contribute to morning stiffness, functional disability, lower hemoglobin levels, fatigue, increased bone resorption, and vascular endothelial dysfunction associated with RA.1,2
References: 1. Choy E. Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis. Rheumatology (Oxford). 2012;51(suppl 5):v3-v11. 8. Gibbs JE, Ray DW. The role of the circadian clock in rheumatoid arthritis. Arthritis Res Ther. 2013;15(1):1-9
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